Regenerating cream with peptides and plant-derived exosomes.

A strategy focused on regeneration, skin structure and barrier function

Skin firmness does not depend on collagen alone.

It depends on an architecture involving the extracellular matrix, collagen, elastin and cells such as fibroblasts, which are responsible for producing and remodelling part of this structure.

As skin ages, these systems change. Fibroblasts progressively alter their activity, the extracellular matrix is remodelled, and some fibroblasts can enter cellular senescence, a state associated with changes in how they function and interact with their environment.

The visible result can be progressively less firm and elastic skin, reduced density, more pronounced wrinkles and changes in the skin's ability to recover.

Cell Reversa addresses these changes through three complementary areas: skin regeneration, the extracellular matrix and skin barrier function.

1. Centella Reversa™: plant biotechnology and cellular communication

At the heart of the formula is 2.5% Centella Reversa™, a technology developed by Vytrus Biotech from Centella asiatica cell cultures.

Unlike a conventional Centella asiatica extract, Centella Reversa™ works with material produced and released by plant cells cultured under controlled conditions.

The technology has been characterised by a secretome rich in peptides, proteins and extracellular vesicles, including an exosomal fraction.

Vytrus has studied Centella Reversa™ in vitro on human dermal fibroblasts, including replicative senescence models and parameters related to procollagen I, elastin and regenerative capacity.

This allows skin ageing to be approached from a broader perspective than simply “adding collagen”: by also focusing on the cells responsible for maintaining the matrix and the signals involved in these processes.

2. Four biomimetic peptides: specific signals

Cell Reversa also contains four biomimetic peptides:

Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-38 and Acetyl Hexapeptide-8.

These are not the same peptides naturally present in Centella Reversa™.

And that distinction is intentional.

Centella Reversa™ provides a complex biological network of plant-derived signals; the biomimetic peptides provide defined signals selected for specific mechanisms.

The first three are primarily focused on processes related to the extracellular matrix, firmness and the appearance of wrinkles, while Acetyl Hexapeptide-8 acts on mechanisms related to expression lines.

The aim is not to accumulate peptides.

It is to make different technologies work complementarily within the same strategy.

3. Skin barrier and comfort

Targeting the signs of ageing should not mean constantly testing the skin's tolerance.

This is why Cell Reversa also contains prebiotic inulin, aloe vera and oat, which help preserve skin balance, maintain hydration and provide comfort.

The result is an advanced anti-ageing formula designed to work progressively on firmness, elasticity, wrinkles and texture, without losing sight of skin barrier function.

Although Cell Reversa could be introduced into an anti-ageing routine from around the age of 30–35, we believe your skin matters more than the age on your ID.

Cell Reversa is particularly suitable when you begin to notice:

• loss of firmness or elasticity;
• reduced skin density;
• more visible wrinkles;
• uneven skin texture;
• skin that needs an anti-ageing treatment but does not tolerate overly intensive approaches well.

It is particularly relevant if you are looking for a firming and anti-wrinkle cream for sensitive skin that combines technologies targeting skin ageing with a formula designed to respect skin barrier function.

It may not be your best choice if you are simply looking for lightweight hydration and your main concern is dehydration or barrier balance. In that case, a specifically hydrating formula may make more sense.

Nor do we believe you need Cell Reversa simply because you have reached a particular age.

The decision should start with what your skin actually needs.

The first thing you will probably notice is comfort.

A rich, enveloping texture that leaves skin nourished and supple without feeling heavy.

Then comes what requires a little more time: skin that progressively looks smoother, firmer and more even, with wrinkles appearing less pronounced.

Cell Reversa was not developed around the idea of demanding more from the skin in order to fight the passage of time.

It was developed around understanding what changes in the skin and which processes we can target cosmetically without compromising its balance.

Regenerating, strengthening and caring are all part of the same strategy.

Apply a small amount to clean, dry skin on the face and neck, morning and/or evening. Massage gently until fully absorbed.

In the morning, always finish your routine with sunscreen.

Cell Reversa + Royal Bakuchiol?

Yes. And the combination makes sense precisely because they are not designed to do exactly the same thing.

Cell Reversa focuses particularly on regeneration, firmness, the extracellular matrix and elasticity.

Royal Bakuchiol Serum, formulated with bakuchiol and niacinamide, broadens the strategy to address other visible signs of ageing, particularly wrinkles, skin texture and uneven tone, while maintaining a high-tolerance approach.

Apply Royal Bakuchiol first, followed by Cell Reversa.

It is a particularly interesting evening combination when looking for a more comprehensive approach to the signs of photoageing without building an unnecessarily aggressive routine.